Oxadiazole, thiadiazole, triazole

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Oxadiazole:

J. Med. Chem. 2002, 45, 3094-3102	1
	2

Procedure 1. The starting materials, ethyl ester (1 equiv.), and oxime amide (1.2 equiv.) were dissolved into THF. NaH (4 equiv.) was added. The resulting mixture was stirred for 6 hours with reflux. The resulting mixture was diluted with ethyl acetate, and washed with brine. The organic layer was dried, and concentrated. The residue was purified by silica gel column.

Triazole:

J. Med. Chem. 2005, 48 (6), 1824

Thiadiazole:

Chem. Heterocycle Compd. 2001, 37 ((), 1102
J. Heterocycle Chem. 1990, 27, 951
J. Heterocycle Chem. 2000, 37 (1), 63