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Amdine Synthesis from alcohol and amine
Glucose to HMF
Ketone a-Chiral Alktlation; Angew. Chem. Int. Ed., DOI:10.1002/anie.200800848
Science, 307, 1080 (2005)

Hartwig reaction? Could it be useful like Buchwald - Hartwig reaction?
Oxidative Indole Coupling
Oxidative Enolate coupling Reaction
Kirk-Petrow (Phenylthio) Methylation
Chiral Nazarov Cyclization
Baeyer Pyridine Synthesis
Pd-catalyzed intramolecular cylization
Sonogashira Reaction
J. Am. Chem. Soc. 2007, 129, 7274

Pd catalyzed C-H amination

C-H amination
J. Org. Chem., 2003, 68, 3563

Cobalt Catalyzed Quinoline Synthesis
Fe-catalyzed C-N Cross Coupling,

Angew.Chem.Int.Ed. 2007, 46, 8862
Gold-Catalyzed Cycloisomerization

Adv. Synth. Catal. 2006, 348, 2501-2508
Povarov Reaction
Asymmetric Hydrogenation of Enamides
OMs in Coupling Reaction
Suzuki-Miyaura reactions
Suzuki Coupling involving Floro-substituent

J. Am. Chem. Soc. 2006, 128, 15964
Ionic Hydrogenation
J. Am. Chem. Soc. 1956, 78, 5832

Dimroth Triazole Synthesis
Pyrazolo[1,5-a]pyridine Synthesis

Bioorg. Med. Chem. Lett. 1999, 9, 97-102
Radical Substitution
Cannizzaro Reaction
NaNO2 Oxidation of Carbon
Fe3+ oxidizes Vitamin E
2-Quinuclidone Synthesis
Cyclopropylketone rearrangement
11-cis-retinal synthesisThe trans double bond between carbon 11 and 12 is isomerized to cis. Hydroxyl group is oxidized to aldehyde. Mechanism ?
Grieco-Elimination
Double Elimination
Beta-Elimination
Artemisinine (Quinghaosu) Reaction, what is the mechanism?
Humulones' isomization. This reaction makes your beer pleasant bitterness.

 (By Movies)
Kawase N-Acyl Rearrangement
Newman-Kwart Rearrangement
Chapmann Rearrangement

Benzilic Rearrangement
Claisen Rearrangement
Amino-Transfer Reaction
Bezodiazepine synthesis, Mechanism?
Ethylation on Pyrimidine
A one-step nitrile synthesis
Floronation
Pyridine Chloronation
Minisci Reaction:What is the detailed reaction mechanism for this reaction?
Oxidation on Pyridine
Nicolaou Oxidation
It is the formation of 2-pyridyldialkylcarbinols by condensation of ketones with pyridine or its homologs in the presence of aluminum or magnesium amalgam.
Unique Displacement used in drug synthesis
Hantzsch Dihydropyridine Synthesis
Traube Purine synthesis
Quinoline Synthesis
The first total synthesis: The first conscious total synthesis of a natural product was the synthesis of urea.
Pinner Amidine Synthesis

The 4 billion dollar drug Nexium (1) uses smiles rearrangement to generate the active compound (2) to inhibit the enzyme. The process is called "omeprazole cycle".
Tetrahydroisoquinoline synthesis. Mechanism?
What is the detailed reaction mechanism for this reaction?
Lebedev Methoxymethylation
Homogentisate formation: What is the mechanism of this reaction? Which enzyme catalyze this reaction?
As little as a nanogram of amino acid can be detected by means of fluorescamine. What is the mechanism of this reaction?
Cholecalciferol is produced by irradiating 7-dehydrocholesterol with ultraviolet light.
Homolytic cleavage reaction
Thiolysis in fatty acid oxidation
AcylCoA reacts with amine.

The hydrolysis of thioester is thermodynamically more favorable than that of an oxygen ester because the double-bond character of C-O bond does not extend significantly to the C-S bond. Consequently, acetyl CoA has a high acteyl group transfer potential.

"Oxaloacetate, the product of the pyruvate carboxylase reaction, is both a stoichiometric intermediate in gluconeogenesis and a catalytic intermediate in the citric acid cycle."
The catalyst used in Stetter reaction is just like Vitamin B1. Mechanism? The thiazolium catalyst functions as a safe surrogate for NaCN.

New reactions

The Direct Acyl-Alkylation of Arynes, J. AM. Chem. Soc. 2005, 127, 5340-5341
Click here to Monthly Chemistry eNewsletter from Sigma-Aldrich, and then click View SlidesShow to learn more.
Click here to learn more. Halogen Dancing
Selective substitution
VNS reaction
Finegan Terazole Synthesis
Indole 3-Acylation
MacMillan's addition cyclization strategy. MacMillan's reagent is originally designed for Stork enamine type of reactions.
Biomimetic Reductive Amination
Shi asymmetric epoxidation

 

MacMillan's addition cyclization strategy. MacMillan's reagent is originally designed for Stork enamine type of reactions.
Biomimetic Reductive Amination

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